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RTOG 9709 Protocol Information

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A Phase III Study to Test the Efficacy of the Prophylactic Use of Oral Pilocarpine to Reduce Hyposalivation and Mucositis Associated With Curative Radiation Therapy in Head and Neck Cancer Patients
Protocol Documents
Current Version Date: 4/1/1999
Principal Investigator: Francis LeVeque, D.D.S .
Primary Objective:

To determine if prophylactic use of pilocarpine can shelter unstimulated and stimulated whole salivary flow by objective measurement (sialometry).

Patient Population:
  • Confirmed histopathologic diagnosis of oral or oropharyngeal squamous cell carcinoma; metastases to the neck from unknown primary provided the dose to >/= 50% of the salivary gland is >/= 50 Gy
  • Karnofsky Performance Score >/= 60
  • Age  >/= 18
  • No prior radiotherapy to the head and neck
  • Primary tumor in oral cavity or oropharynx
  • No uncontrolled asthma, acute iritis, or narrow angle glaucoma

 

Target Accrual: 244
Current Accrual: 249
Status: Terminated
Date: 10/18/2002
Participating Sites:
Advocate Lutheran General Hospital Park Ridge IL
Arizona Oncology Services Foundation Scottsdale AZ
Atlanta Regional CCOP Atlanta GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Hospital of East Tennessee Knoxville TN
Bay Area Tumor Institute Oakland CA
Bayfront Cancer Care Center St. Petersburg FL
Boston Veteran's Affairs Medical Center Boston MA
Cancer Center of Santa Barbara Santa Barbara CA
Cape Cod Hospital Hyannis MA
Caritas Regional Cancer Center Louisville KY
Case Western Reserve University Cleveland OH
Central Illinois CCOP Decatur IL
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Foundation Cleveland OH
Columbus CCOP Columbus OH
Cooper Hospital University Medical Center Camden NJ
Cross Cancer Institute Edmonton, Alberta
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
East Carolina University Greenville NC
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Finley Hospital Dubuque IA
Florida Hospital Orlando Orlando FL
Fox Chase Cancer Center Philadelphia PA
Good Samaritan Hospital Corvallis OR
Greater Baltimore Medical Center Baltimore MD
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbin Clinic Rome GA
Harbor Hospital Center Baltimore MD
Health Sciences North Sudbury, Ontario
Holmes Regional Medical Center Melbourne FL
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Jackson-Madison County General Hospital Jackson TN
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Long Beach Memorial Medical Center-Todd Cancer Institute Long Beach CA
Mainline Health CCOP Wynnewood PA
Mayo Clinic Rochester MN
McGill University Department of Oncology Montreal
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Montefiore Medical Center - Moses Campus Bronx NY
Montgomery Cancer Center, LLC Montgomery AL
Morton Plant Hospital Clearwater FL
Mount Sinai Medical Center Miami Beach FL
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Mississippi Medical Center Cancer Center Tupelo MS
North Shore-LIJ Health System CCOP Manhasset NY
Northern Indiana Cancer Research Consortium South Bend IN
Northwest Community Clinical Oncology Program Tacoma WA
Northwest Community Hospital Arlington Heights IL
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
Peninsula Regional Medical Center Salisbury MD
Pomona Valley Hospital Medical Center Pomona CA
Providence Alaska Medical Center Anchorage AK
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Richard L. Roudebush VA Medical Center Indianapolis IN
Romagosa Radiation Oncology Center Lafayette LA
Saint Agnes Medical Center Fresno CA
Saint John Medical Center Tulsa OK
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sanford Roger Maris Cancer Center Fargo ND
Santa Cruz Radiation Oncology Santa Cruz CA
Santa Rosa Memorial Hospital Santa Rosa CA
Sarasota Radiation & Medical Oncology Center Sarasota FL
Saskatoon Cancer Centre Saskatoon, Saskatchew
South Georgia Medical Center/Pearlman Cancer Center Valdosta GA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
St Michael's Hospital Milwaukee WI
State University of New York Downstate Medical Center Brooklyn NY
Sutter Cancer Research Consortium Novato CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
The Don and Sybil Harrington Cancer Center Amarillo TX
The Research Institute of the McGill University Health Centre (MUHC) Montreal
Thunder Bay Regional Health Science Centre Thunder Bay, Ontario
Toledo Community Hospital Oncology Program CCOP Toledo OH
Trinity Cancer Care Center Minot ND
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Colorado Hospital Aurora CO
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Missouri - Ellis Fischel Columbia MO
University of New Mexico Cancer Center Albuquerque NM
University of South Alabama Mobile AL
University of Virginia Cancer Center Charlottesville VA
University of Wisconsin Hospital and Clinics Madison WI
UP Health System Marquette Marquette MI
UPMC-Mercy Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
Vanderbilt University/Ingram Cancer Center Nashville TN
Veterans Administration New Jersey Health Care System East Orange NJ
Virginia Baptist Hospital Lynchburg VA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington Cancer Institute Washington DC
Wayne State University/Karmanos Cancer Institute Detroit MI
WellSpan Health-York Hospital York PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheaton Franciscan Healthcare - Saint Joseph Milwaukee WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 4/13/2011

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