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RTOG 9710 Protocol Information

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A Phase II Study of Conventional Radiation Therapy Followed with Recombinant Interferon Beta for Supratentorial Glioblastoma
Protocol Documents
Current Version Date: 7/1/1999
Principal Investigator: W.K. Alfred Yung, M.D.
Primary Objective:

To determine if recombinant interferon beta given intramuscularly three times per week after conventional RT may improve the median survival time of adults with newly diagnosed supratentorial glioblastoma.

Patient Population:
  • Histopathologically confirmed glioblastoma multiforme (with areas of necrosis)
  • The tumor must be supratentorial in location
  • Age >/= 18
  • KPS >/=60
  • No prior radiation therapy to head or neck area, chemotherapy or radiosensitizer.
  • Absolute Neutrophil count >/=1500, platelets >/=100,000, BUN </= 25, Creatinine </= 1.5, Bilirubin </= 2.0, Hgb >/= 10 gm
  • No malignancy (within the past five years) except non-melanomatous skin cancer or carcinoma in-situ of the cervix
  • SGPT or SGOT </= 2 x normal range
  • Signed study-specific consent form
Target Accrual: 108
Current Accrual: 109
Status: Terminated
Date: 6/30/2010
Participating Sites:
21st Century Oncology Ft. Myers FL
Allegiance Health Jackson MI
AtlantiCare Regional Medical Center Pomona NJ
Baptist Cancer Institute Jacksonville FL
Baptist Health Paducah Paducah KY
Baptist Hospital of East Tennessee Knoxville TN
Beaumont Hospital - Dearborn Dearborn MI
Central Illinois CCOP Decatur IL
Cleveland Clinic Foundation Cleveland OH
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Good Samaritan Hospital Corvallis OR
Greater Baltimore Medical Center Baltimore MD
Gundersen Lutheran Medical Center La Crosse WI
Hurley Medical Center Flint MI
Inspira Medical Center Vineland Vineland NJ
Jackson-Madison County General Hospital Jackson TN
John F Kennedy Medical Center Edison NJ
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lewis and Faye Manderson Cancer Center Tuscaloosa AL
Liberty Hospital Liberty MO
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Marshfield Clinic Marshfield WI
McKay-Dee Hospital Center Ogden UT
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Hospital Pittsburgh PA
Methodist Cancer Center Omaha NE
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mobile Infirmary Medical Center Mobile AL
Montefiore Medical Center - Moses Campus Bronx NY
Mount Sinai Medical Center Miami Beach FL
Naval Medical Center - Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northwest Community Clinical Oncology Program Tacoma WA
Norwalk Hospital Norwalk CT
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Roswell Park Cancer Institute Buffalo NY
Saint Agnes Medical Center Fresno CA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's of Michigan Saginaw MI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
South Georgia Medical Center/Pearlman Cancer Center Valdosta GA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
Sparrow Hospital Lansing MI
St Mary Regional Cancer Center Langhorne PA
St. Francis Medical Center Trenton NJ
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
Thomas Jefferson University Hospital Philadelphia PA
UF Cancer Center at Orlando Health Orlando FL
University of Arkansas for Medical Sciences Little Rock AR
University of Kentucky/Markey Cancer Center Lexington KY
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of South Alabama Mobile AL
University of Vermont Medical Center Burlington VT
Upstate Carolina CCOP Spartanburg SC
Utah Valley Regional Medical Center Provo UT
Virtua Memorial Mount Holly NJ
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Updated: 4/13/2011

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