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RTOG 9712 Protocol Information

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A Phase I Dose Escalation Study of Thoracic Irradiation With Concurrent Chemotherapy for Patients With Limited Small Cell Lung Cancer
Protocol Documents
Current Version Date: 9/21/2001
Principal Investigator: Ritsuko Komaki, M.D.
Primary Objective:

To find the maximum tolerated dose of thoracic radiation using an accelerated boost with concurrent chemotherapy. To increase local control by increased radiation dose in thorax to improve survival. To reduce toxicity to the esophagus and/or the lung.

Patient Population:
  • Histologic or unequivocal cytologic proof of SCLC with measurable or evaluable disease.
  • Clinically limited disease with no prior chemotherapy or radiotherapy.
  • Absolute granucocytes >/=1500, platelets >/= 150,000, bilirubin ,/=1.5 mg/d., creatinine </= 1.5 mg/d.
  • KPS >/= 70; age >/=18.
  • No pericardial or pleural effusion on CXR regardless of cytology.
  • No previous (within 2 years) or concurrent malignancy except  for non-melanotic skin cancer or carcinoma in situ of cervix.
  • Signed study-specific consent form.
Target Accrual: 20-66
Current Accrual: 64
Status: Terminated
Date: 6/30/2010
Participating Sites:
21st Century Oncology, Inc. Ft. Myers FL
Akron General Medical Center Akron OH
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Health Paducah Paducah KY
Baptist Hospital of Miami Miami FL
Bay Area Tumor Institute Oakland CA
Bayfront Cancer Care Center St. Petersburg FL
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Caritas Regional Cancer Center Louisville KY
Cleveland Clinic Foundation Cleveland OH
Clifton Springs Hospital and Clinic Clifton Springs NY
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus CCOP Columbus OH
Community Medical Center Toms River NJ
Cottonwood Hospital Medical Center Murray UT
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Good Samaritan Hospital Corvallis OR
Grant Medical Center Columbus OH
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Hospital ROC Daytona Beach FL
Hillcrest Hospital Cancer Center Mayfield Heights OH
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Julie and Ben Rogers Cancer Institute Beaumont TX
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Liberty Hospital Liberty MO
Louisiana State University Health Science Center New Orleans LA
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Hospital Pittsburgh PA
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Missouri Valley Cancer Consortium Omaha NE
Montefiore Medical Center - Moses Campus Bronx NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Newark Beth Israel Medical Center Newark NJ
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northridge Hospital Medical Center Northridge CA
Northwest Community Clinical Oncology Program Tacoma WA
Pocono Medical Center East Strousburg PA
Pomona Valley Hospital Medical Center Pomona CA
Providence Alaska Medical Center Anchorage AK
Regional Hospital of Scranton Scranton PA
Saint Agnes Medical Center Fresno CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Stanford Cancer Institute Palo Alto Palo Alto CA
Summa Akron City Hospital/Cooper Cancer Center Akron OH
The Cancer Center for Southern Kentucky Bowling Green KY
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
Trinity Cancer Care Center Minot ND
UCLA Medical Center Los Angeles CA
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Kentucky/Markey Cancer Center Lexington KY
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Pennsylvania Medical Center Philadelphia PA
Utah Valley Regional Medical Center Provo UT
Vanderbilt University/Ingram Cancer Center Nashville TN
Virtua Memorial Mount Holly NJ
Washington University School of Medicine St. Louis MO
Wayne State University/Karmanos Cancer Institute Detroit MI
West Penn Hospital Pittsburgh PA
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/13/2011

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