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RTOG 9714 Protocol Information

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Randomized Trial of Palliative Radiation Therapy For Osseous Metastases: A Study of Palliation of Symptoms and Quality of Life For Osseous Metastases: A Study of Palliation of Symptoms and Quality of Life
Protocol Documents
Current Version Date: 4/30/2001
Principal Investigator: William F. Hartsell, M.D.
Primary Objective:

To determine whether 8 Gy in a single fraction provides equivalent pain and narcotic relief compared to 30 Gy in 10 fractions for patients with painful bone metastases.

Patient Population:
  • Histologically-proven breast or prostate malignancy.
  • Radiographic evidence of bone metastasis with pain at that site (painful metastases to skull, hands, and feet are not eligible).
  • Life expectancy of at least 3 months.
  • Karnofsky Performance Score >/=40, age >/=18.
  • BPI score >/=5 or BPI score < 5 with >/=60 mg of morphine (or equivalent) per day.
  • No introduction of systemic therapy within 30 days of randomization. See Section 3.1.6.
  • No prior radiotherapy or palliative surgery to the painful site.
  • No systemic radio-isotopes (e.g. Sr89) in past 30 days.
  • Not previously randomized to this study.
  • Signed study-specific consent form.
Target Accrual: 938
Current Accrual: 949
Status: Terminated
Date: 2/19/2009
Participating Sites:
Adena Regional Medical Center Chillicothe OH
Advocate Good Shepherd Hospital Barrington IL
Advocate Lutheran General Hospital Park Ridge IL
Albany Medical Center Albany NY
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
AMITA Health Alexian Brothers Medical Center Elk Grove Village IL
Anne Arundel Medical Center Annapolis MD
Atlanta Regional CCOP Atlanta GA
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute CCOP Memphis TN
Baptist Health Lexington Lexington KY
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville KY
Baptist Hospital of East Tennessee Knoxville TN
Bay Area Tumor Institute Oakland CA
Bayfront Cancer Care Center St. Petersburg FL
BCCA-Vancouver Cancer Centre Vancouver, BC
BCCA-Vancouver Island Cancer Centre Victoria, BC
Boston Veteran's Affairs Medical Center Boston MA
Brooke Army Medical Center Fort Sam Houston TX
California Cancer Center - Fresno Fresno CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Treatment Center Wooster OH
Cape Cod Hospital Hyannis MA
Carle Cancer Center Urbana IL
Carolinas HealthCare System NorthEast Concord NC
Case Western Reserve University Cleveland OH
Central Illinois CCOP Decatur IL
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke, Quebec
Champlain Valley Physicians Hospital Medical Center Plattsburgh NY
Christiana Care Health System-Christiana Hospital Newark DE
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal Montreal
CHUM - Hopital Notre-Dame Montreal Quebec
City of Hope Comprehensive Cancer Center Duarte CA
Cleveland Clinic Foundation Cleveland OH
Clifton Springs Hospital and Clinic Clifton Springs NY
Colorado Cancer Research Program CCOP Denver CO
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus CCOP Columbus OH
Community Medical Center Toms River NJ
Cooper Hospital University Medical Center Camden NJ
Cross Cancer Institute Edmonton, Alberta
Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Deaconess Medical Center Spokane WA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctor H. Bliss Murphy Cancer Centre St. John's, NL
East Carolina University Greenville NC
East Bay Radiation Oncology Center Castro Valley CA
East Jefferson General Hospital Metairie LA
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Elliot Hospital Manchester NH
Faxton-Saint Luke's Healthcare Utica NY
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Geisinger Medical Center Danville PA
Geisinger Wyoming Valley/Henry Cancer Center Wilkes Barre PA
Good Samaritan Hospital Corvallis OR
Grand View Hospital Sellersville PA
Grant Medical Center Columbus OH
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbor Hospital Center Baltimore MD
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hillcrest Hospital Cancer Center Mayfield Heights OH
Holmes Regional Medical Center Melbourne FL
Horizon Health Network-Saint John Regional Hospital Saint John, NB
Huntington Memorial Hospital Pasadena CA
Huntsman Cancer Institute/University of Utah Salt Lake City UT
Huntsville Hospital Huntsville AL
Hurley Medical Center Flint MI
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
Ingham Regional Medical Center Lansing MI
Inspira Medical Center Vineland Vineland NJ
Jackson-Madison County General Hospital Jackson TN
John F Kennedy Medical Center Edison NJ
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore MD
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Keesler Medical Center Keesler AFB MS
Lake University Ireland Cancer Center Mentor OH
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital-Cedar Crest Allentown PA
Lexington Clinic Cancer Center Lexington KY
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
London Regional Cancer Program London Ontario
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
M D Anderson Cancer Center Houston TX
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Cancer Center Boston MA
Mayo Clinic Rochester MN
McGill University Department of Oncology Montreal
McLaren Cancer Institute-Flint Flint MI
Medical University of South Carolina Charleston SC
Memorial Sloan Kettering Cancer Center New York NY
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy Regional Cancer Center Redding CA
Mesa Lutheran Hospital Mesa AZ
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Missouri Valley Cancer Consortium Omaha NE
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
Montefiore Medical Center - Moses Campus Bronx NY
Mount Sinai Medical Center Miami Beach FL
Mount Sinai Union Square New York NY
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Naval Medical Center - Portsmouth Portsmouth VA
Nebraska Methodist Hospital Omaha NE
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York Medical College Valhalla NY
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Newark Beth Israel Medical Center Newark NJ
North Shore-LIJ Health System CCOP Manhasset NY
Northridge Hospital Medical Center Northridge CA
Northwest Community Clinical Oncology Program Tacoma WA
Northwest Community Hospital Arlington Heights IL
Northwestern University Chicago IL
Ochsner Medical Center Jefferson New Orleans LA
Odette Cancer Centre- Sunnybrook Health Sciences Centre Toronto, Ontario
Ohio State University Comprehensive Cancer Center Columbus OH
Oncology Institute of Greater Lafayette Lafayette IN
Penn State Milton S Hershey Medical Center Hershey PA
Presbyterian Kaseman Hospital Albuquerque NM
QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Richard L. Roudebush VA Medical Center Indianapolis IN
Romagosa Radiation Oncology Center Lafayette LA
Roswell Park Cancer Institute Buffalo NY
Saint Agnes Medical Center Fresno CA
Saint Francis Medical Center Trenton NJ
Saint John Medical Center Tulsa OK
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Sanford Roger Maris Cancer Center Fargo ND
Santa Rosa Memorial Hospital Santa Rosa CA
Sarasota Radiation & Medical Oncology Center Sarasota FL
Saskatoon Cancer Centre Saskatoon, Saskatchew
Sentara Martha Jefferson Hospital Charlottesville VA
Sentara Rockingham Memorial Hospital Hahn Cancer Center Harrisonburg VA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southern Wisconsin Radiotherapy Center Madison WI
Southwestern Vermont Medical Center Bennington VT
Sparrow Hospital Lansing MI
St Mary Regional Cancer Center Langhorne PA
St. Anthony Cancer Care Institute at St. Anthony Hospital Oklahoma City OK
Stanford Cancer Institute Palo Alto Palo Alto CA
State University of New York Downstate Medical Center Brooklyn NY
State University of New York Upstate Medical University Syracuse NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Research Consortium Novato CA
Sutter Medical Center Sacramento Sacramento CA
Swedish Medical Center-First Hill Seattle WA
The Cancer Center for Southern Kentucky Bowling Green KY
The Christ Hospital Cincinnati OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Research Institute of the McGill University Health Centre (MUHC) Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thomas Jefferson University Hospital Philadelphia PA
Thunder Bay Regional Health Science Centre Thunder Bay, Ontario
Toledo Community Hospital Oncology Program CCOP Toledo OH
Tom Baker Cancer Centre Calgary, Alberta
Trinity Cancer Care Center Minot ND
Tulane University Health Sciences Center New Orleans LA
UCLA / Jonsson Comprehensive Cancer Center Los Angeles CA
UCSF Medical Center-Mount Zion San Francisco CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
UHHS-Chagrin Highlands Medical Center Orange Village OH
UHHS-Westlake Medical Center Westlake OH
United Hospital St. Paul MN
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Arizona Medical Center-University Campus Tucson AZ
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Chicago Comprehensive Cancer Center Chicago IL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Hawaii Cancer Center Honolulu HI
University of Illinois Hospital Chicago IL
University of Iowa/Holden Comprehensive Cancer Center Iowa City IA
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Missouri - Ellis Fischel Columbia MO
University of New Mexico Cancer Center Albuquerque NM
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of Rochester Rochester NY
University of South Alabama Mobile AL
University of Tennessee Health Science Center Memphis TN
University of Texas Medical Branch Galveston TX
University of Vermont Medical Center Burlington VT
University of Wisconsin Hospital and Clinics Madison WI
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Mercy Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
USC / Norris Comprehensive Cancer Center Los Angeles CA
Valley Hospital Paramus NJ
Valley Medical Oncology Consultants Pleasanton CA
Vanderbilt University/Ingram Cancer Center Nashville TN
Veterans Administration Long Beach Medical Center Long Beach CA
Veterans Affairs Medical Center - Miami, Florida Miami FL
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington Cancer Institute Washington DC
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wichita CCOP Wichita KS
Wilford Hall Medical Center Lackland AFB TX
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/13/2011

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