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RTOG 9803 Protocol Information

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Phase I/II Radiation Dose Escalation Study Applying Conformal Radiation Therapy in Supratentorial Glioblastoma Multiforme
Protocol Documents
Current Version Date: 10/15/2001
Principal Investigator: Jeff Michalski, M.D.
Primary Objective:

Test feasibility and toxicity of escalating doses of conformal radiation therapy planned with 3D treatment planning in patients with glioblastoma multiforme.

Patient Population:

 

  • Newly diagnosed histologically-confirmed glioblastoma multiforme with areas of necrosis
  • Supratentorial tumor
  • Therapy beginning within 5 weeks after surgery but within one week after registration
  • No prior chemotherapy or radiotherapy to the head and neck
  • Age > 18
  • Karnofsky performance status > 60
  • Neurologic functional status 0, 1, 2 or 3
  • emoglobin > 9 gm, absolute neutrophil count > 1500 mm3 , platelets > 100,000
  • BUN < 30 mg, creatinine < 1.8 mg, bilirubin < 2 mg, and SGPT or SGOT < twice normal range
  • Normal chest x-ray
  • Signed study specific consent form prior to registration
 
Required Sample Size: Dose tolerance dependent
Target Accrual:
Current Accrual: 209
Status: Terminated
Date: 6/30/2010
Participating Sites:
21st Century Oncology Ft. Myers FL
ACR Clinical Research Center Philadelphia PA
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Allegiance Health Jackson MI
AnMed Health Cancer Center Anderson SC
Arizona Oncology Services Foundation Scottsdale AZ
Baptist Cancer Institute CCOP Memphis TN
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Brooke Army Medical Center Fort Sam Houston TX
California Cancer Center - North Fresno Fresno CA
Cancer Treatment Center Wooster OH
Case Western Reserve University Cleveland OH
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
Covenant Medical Center-Lakeside Lubbock TX
Cross Cancer Institute Edmonton, Alberta
Dayton CCOP Kettering OH
Dixie Medical Center Regional Cancer Center East St. George UT
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Genesys Hurley Cancer Institute Flint MI
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Harbin Clinic Rome GA
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hurley Medical Center Flint MI
Image-Guided Therapy QA Center (ITC) St. Louis MO
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis IN
John F Kennedy Medical Center Edison NJ
Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario
Kansas City CCOP Prairie Village KS
Lake/University Seidman Cancer Center Mentor OH
Lankenau Medical Center Wynnewood PA
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lexington Clinic Cancer Center Lexington KY
Liberty Hospital Liberty MO
London Regional Cancer Program London Ontario
Loyola University Medical Center Maywood IL
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
MetroHealth Medical Center Cleveland OH
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mobile Infirmary Medical Center Mobile AL
Mount Sinai Medical Center Miami Beach FL
Mount Sinai Union Square New York NY
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
Northwest Community Clinical Oncology Program Tacoma WA
Northwest Community Hospital Arlington Heights IL
Pomona Valley Hospital Medical Center Pomona CA
Providence Alaska Medical Center Anchorage AK
Providence St. Joseph Medical Center - Disney Family CA Ctr Burbank CA
Radiation Medical Group, Inc. San Diego CA
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Associates of Sacramento Sacramento CA
Rapid City Regional Hospital Rapid City SD
Roswell Park Cancer Institute Buffalo NY
Rutherford Hospital Rutherfordton NC
Saint Agnes Medical Center Fresno CA
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Peter's University Hospital New Brunswick NJ
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Siteman Cancer Center at Saint Peters Hospital St. Peters MO
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
St Joseph's Hospital Medical Center Stockton CA
St. Anthony Cancer Care Institute at St. Anthony Hospital Oklahoma City OK
Summa Akron City Hospital/Cooper Cancer Center Akron OH
The Cancer Center for Southern Kentucky Bowling Green KY
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Valley Hospital Paramus NJ
Thomas Jefferson University Hospital Philadelphia PA
UCHealth Memorial Hospital Central Colorado Springs CO
UHHS - Chagrin Highlands Orange Village OH
UHHS-Westlake Medical Center Westlake OH
Union Hospital Terre Haute IN
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of New Mexico Cancer Center Albuquerque NM
University of South Alabama Mobile AL
University of Texas Medical Branch Galveston TX
University of Wisconsin Hospital and Clinics Madison WI
Upstate Carolina CCOP Spartanburg SC
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington University School of Medicine St. Louis MO
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
Wilford Hall USAF Medical Center Lackland AFB TX
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/13/2011

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