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RTOG 9902 Protocol Information

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A Phase III Protocol of Total Androgen Suppression (TAS) and Radiation Therapy (RT) vs TAS and RT Followed by Chemotherapy with Paclitaxel, Estramustine, and Etoposide (TEE) for Localized, High-Risk, Prostate Cancer
Protocol Documents
Current Version Date: 1/31/2007
Principal Investigator: Howard M. Sandler, M.D.
Primary Objective:

To assess the relative efficacy of the combination of androgen suppression + RT followed by androgen suppression vs. AS + RT followed by TEE chemotherapy + androgen suppression in a population of patients with clinically-localized prostate cancer with unfavorable prognostic factors. The primary endpoint will be survival, but biochemical control (freedom from PSA failure), local control, disease free survival, and freedom from distant metastasis will also be assessed.

Patient Population:

Histologically-confirmed prostate cancer with either PSA 20-100 and GS > 7 (any T stage) or clinical stage > T2 and GS > 8 (PSA < = 100) (M0)

Target Accrual: 1440
Current Accrual: 397
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology, Inc. Ft. Myers FL
Adena Regional Medical Center Chillicothe OH
Advocate Good Samaritan Hospital Downers Grove IL
Advocate Good Shepherd Hospital Barrington IL
Advocate Illinois Masonic Medical Center Chicago IL
Akron General Medical Center Akron OH
Allegiance Health Jackson MI
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
AnMed Health Cancer Center Anderson SC
Anne Arundel Medical Center Annapolis MD
AtlantiCare Regional Medical Center Pomona NJ
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Health Lexington Lexington KY
Baptist Health Paducah Paducah KY
Baptist Hospital of Miami Miami FL
Baton Rouge General Medical Center Baton Rouge LA
Bay Area Medical Center Marinette WI
Bay Medical Center Panama City FL
Beaumont Hospital-Dearborn Dearborn MI
Benefis Healthcare- Sletten Cancer Institute Great Falls MT
Beth Israel Medical Center New York NY
Billings Clinic Cancer Center Billings MT
Bixby Medical Center Adrian MI
Bozeman Deaconess Hospital Cancer Center Bozeman MT
Bryn Mawr Hospital Bryn Mawr PA
California Cancer Center CGOP Fresno CA
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Institute of New Mexico Santa Fe NM
Cancer Treatment Center Wooster OH
Caritas Regional Cancer Center Louisville KY
Carle Cancer Center Urbana IL
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Carolinas Medical Center/Levine Cancer Institute Charlotte NC
Case Western Reserve University Cleveland OH
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene NH
Christiana Care Health System-Christiana Hospital Newark DE
City of Hope Comprehensive Cancer Center Duarte CA
Colorado Cancer Research Program CCOP Denver CO
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus CCOP Columbus OH
Columbus Regional Hospital Columbus IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
CoxHealth South Hospital Springfield MO
Danville Regional Medical Center Danville VA
Dartmouth Hitchcock Medical Center Lebanon NH
David Grant United States Air Force Medical Center Travis AFB CA
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Doctor H. Bliss Murphy Cancer Centre St. John's, NL
Doctors Hospital Columbus OH
Don & Sybil Harrington Cancer Center Amarillo TX
Einstein Medical Center Philadelphia Philadelphia PA
Elizabeth General Medical Center Elizabeth NJ
Elliot Hospital Manchester NH
Enloe Medical Center Chico CA
Faxton-Saint Luke's Healthcare Utica NY
Finley Hospital Dubuque IA
Flower Hospital Sylvania OH
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Froedtert Memorial Lutheran Hospital Milwaukee WI
Genesis Healthcare System Cancer Care Center Zainesville OH
Genesys Hurley Cancer Institute Flint MI
Grady Memorial Hospital Delaware OH
Grant Medical Center Columbus OH
Greater Baltimore Medical Center Baltimore MD
Greater Baltimore Medical Center Baltimore MD
Green Bay Oncology at Saint Vincent Hospital Green Bay WI
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Hospital ROC Daytona Beach FL
Harbin Clinic Rome GA
Harbor Hospital Center Baltimore MD
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Hurley Medical Center Flint MI
Huron Valley Hospital Commerce Township MI
Idaho Urologic Institute-Meridian Meridian ID
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Intermountain Medical Center Murray UT
Iowa Methodist Medical Center Des Moines IA
John F Kennedy Medical Center Edison NJ
John Muir Medical Center-Concord Concord CA
John Muir Medical Center-Walnut Creek Concord CA
Julie and Ben Rogers Cancer Institute Beaumont TX
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Kentucky Clinic Berea Berea KY
Lake Huron Medical Center Port Huron MI
Lake/University Seidman Cancer Center Mentor OH
Lancaster General Hospital Lancaster PA
Lankenau Medical Center Wynnewood PA
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Licking Memorial Hospital Newark OH
Lima Memorial Hospital Lima OH
Logan Regional Hospital Logan UT
London Regional Cancer Program London Ontario
Los Angeles County-USC Medical Center Los Angeles CA
Louisiana State University Health Science Center New Orleans LA
Lovelace Medical Center-Downtown Albuquerque NM
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Mainline Health CCOP Wynnewood PA
Marietta Memorial Hospital Marietta OH
Marin General Hospital Greenbrae CA
Mary Bird Perkins Cancer Center Baton Rouge LA
Massachusetts General Hospital Boston MA
Mayo Clinic in Arizona Scottsdale AZ
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Medical University of Ohio Toledo OH
Mercy Cancer Center Elyria OH
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Springfield Springfield MO
Mercy Saint Anne Hospital Toledo OH
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Methodist Hospital Philadelphia PA
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Mobile Infirmary Medical Center Mobile AL
Monmouth Medical Center Long Branch NJ
Montana Cancer Consortium CCOP Billings MT
Mount Carmel Health Center West Columbus OH
Naval Medical Center - Portsmouth Portsmouth VA
Nevada Cancer Research Foundation CCOP Las Vegas NV
North Coast Cancer Care Sandusky OH
North Shore-LIJ Health System CCOP Manhasset NY
Northern Indiana Cancer Research Consortium South Bend IN
Northern Rockies Radiation Oncology Center Billings MT
Northridge Hospital Medical Center Northridge CA
Northwest Community Clinical Oncology Program Tacoma WA
Northwestern University Chicago IL
Novant Health Presbyterian Medical Center Charlotte NC
Ochsner Medical Center Jefferson New Orleans LA
Oncology Institute of Greater Lafayette Lafayette IN
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
Palo Alto Medical Foundation Health Care Palo Alto CA
Paoli Memorial Hospital Paoli PA
Pomona Valley Hospital Medical Center Pomona CA
Porter Adventist Hospital Denver CO
Presbyterian Kaseman Hospital Albuquerque NM
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiation Oncology Center Alliance OH
Radiation Therapy Hosp/Fitzsimon Aurora CO
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Rex Cancer Center Raleigh NC
Richland Memorial Hospital Columbia SC
Riverside Methodist Hospital Columbus OH
Rocky Mountain Oncology Casper WY
Rutland Regional Medical Center Rutland VT
Saint Agnes Medical Center Fresno CA
Saint Alphonsus Cancer Care Center-Boise Boise ID
Saint Ann's Hospital Westerville OH
Saint Charles Hospital Oregon OH
Saint John Hospital and Medical Center Grosse Pointe Woods MI
Saint John Macomb-Oakland Hospital Warren MI
Saint John Medical Center Tulsa OK
Saint John Regional Hospital Saint John, NB
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Mercy Oakland Pontac MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Mary Mercy Hospital Livonia MI
Saint Mary's Hospital and Regional Medical Center Grand Junction CO
Saint Mary's of Michigan Saginaw MI
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay WI
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Saint Vincent Mercy Medical Center Toledo OH
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Saskatoon Cancer Centre Saskatoon, Saskatchew
SCL Health Saint Joseph Hospital Denver CO
Scott and White Memorial Hospital Temple TX
Sentara Rockingham Memorial Hospital Hahn Cancer Center Harrisonburg VA
Sequoia Regional Cancer Center Visalia CA
Smilow Cancer Hospital Care Center at Saint Francis Hartford CT
South Suburban Oncology Center Quincy MA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southern Ohio Medical Center Portsmouth OH
Southern Wisconsin Radiotherapy Center Madison WI
Southwestern Vermont Medical Center Bennington VT
Sparrow Hospital Lansing MI
Spartanburg Medical Center Spartanburg SC
Springfield Regional Medical Center Springfield OH
St Anne's Hospital Fall River MA
St. Claire Cancer Treatment Center Morehead KY
St. Francis Medical Center Trenton NJ
St. Louis University Hospital St. Louis MO
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Summa Barberton Hospital Barberton OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
Sutter Solano Medical Center Vallejo CA
Tallahassee Memorial HealthCare Tallahassee FL
The Christ Hospital Cincinnati OH
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Mark H Zangmeister Center Cols OH
The Research Institute of the McGill University Health Centr Montreal
The Toledo Hospital/Toledo Children's Hospital Toledo OH
Thedacare Cancer Institute Appleton WI
Thomas Jefferson University Hospital Philadelphia PA
Toledo Clinic Cancer Centers-Adrian Adrian MI
Toledo Clinic Cancer Centers-Maumee Maumee OH
Toledo Community Hospital Oncology Program CCOP Toledo OH
Torrance Memorial Medical Center Torrance CA
Trinity Cancer Care Center Minot ND
UCHealth Memorial Hospital Central Colorado Springs CO
UCSF Medical Center-Mount Zion San Francisco CA
Union Hospital Terre Haute IN
United Hospital St. Paul MN
University Medical Center New Orleans New Orleans LA
University Medical Center of Princeton at Plainsboro Princeton NJ
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Kentucky/Markey Cancer Center Lexington KY
University of Maryland/Greenebaum Cancer Center Baltimore MD
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Missouri - Ellis Fischel Columbia MO
University of New Mexico Cancer Center Albuquerque NM
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
University of South Alabama Mobile AL
University of Southern California Los Angeles CA
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Vermont Medical Center Burlington VT
UP Health System Marquette Marquette MI
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Vassar Brothers Medical Center Poughkeepsie NY
Veterans Administration Hospital-East Orange Campus East Orange NJ
Veteran's Administration Medical Center - Lexington Lexington KY
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virtua Memorial Mount Holly NJ
Virtua Voorhees Voorhees NJ
Wake Forest University Health Sciences Winston-Salem NC
Warren Radiation Therapy Center Warren NJ
Washington University School of Medicine St. Louis MO
Wayne Memorial Hospital Goldsboro NC
Wayne Radiation Oncology Goldsboro NC
Wayne State University/Karmanos Cancer Institute Detroit MI
Welch Cancer Center Sheridan WY
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
William Beaumont Hospital - Troy Troy MI
William Beaumont Hospital-Royal Oak Royal Oak MI
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 11/12/2013

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