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RTOG 9905 Protocol Information

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A Phase III Study of Adjuvant Postoperative Irradiation With or Without Cisplatin/Paclitaxel Chemotherapy Following TAH/BSO for Patients With Endometrial Cancer
Protocol Documents
Current Version Date: 6/27/2002
Principal Investigator: Kathryn M. Greven, M.D.
Primary Objective:
  • To test whether the addition of chemotherapy to radiation improves the relapse-free survival for endometrial cancer patients.
  • To determine patterns of recurrence associated with each treatment arm.
  • To determine the acute and late toxicity profiles associated with each treatment arm.
Patient Population:
  • Patients must have had a hysterectomy (total abdominal, vaginal hysterectomy, or laparoscopic-assisted vaginal hysterectomy) and bilateral salpingo-oophorectomy no more than 8 weeks prior to start of radiation therapy
  • No prior chemotherapy or radiation therapy
  • Risk factors: patients must fit one of the following: uterine-confined Grade 2 or 3 with myometrial invasion >50% (Stages IC or IIA); or uterine-confined Grade 2 or 3 with stromal invasion of cervix (Stage IIB)
  • No known extrauterine metastases, no known gross residual disease, no known positive peritoneal cytology or distant metastases
  • Zubrod Performance Status 0-1
  • ANC 1800 /mm3, platelets ≥ 100,000/mcl
  • Acceptable hepatic and renal function: creatinine 1.5 mg%, bilirubin ≤ 1.5 mg/dl and SGOT ≤ 2 x normal
  • No medical contraindications to chemotherapy or radiation therapy
  • Signed study-specific informed consent form
Target Accrual: 436
Current Accrual: 50
Status: Terminated
Date: 6/4/2004
Participating Sites:
Alta Bates Summit Medical Center-Herrick Campus Berkeley CA
Arizona Oncology Services Foundation Scottsdale AZ
AtlantiCare Regional Medical Center Pomona NJ
Aurora Saint Luke's Medical Center Milwaukee WI
Baptist Cancer Institute Jacksonville FL
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville KY
Baptist Hospital of East Tennessee Knoxville TN
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Brooke Army Medical Center Fort Sam Houston TX
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Treatment Center Wooster OH
Capital Health Medical Center-Hopewell Pennington NJ
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke, Quebec
Christiana Care Health System-Christiana Hospital Newark DE
Cleveland Clinic Akron General Akron OH
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Columbus Regional Hospital Columbus IN
Community Howard Regional Health Kokomo IN
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
Cottonwood Hospital Medical Center Murray UT
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Don & Sybil Harrington Cancer Center Amarillo TX
Duke University Medical Center Durham NC
East Bay Radiation Oncology Center Castro Valley CA
Einstein Medical Center Philadelphia Philadelphia PA
Emory University Hospital/Winship Cancer Institute Atlanta GA
Faxton-Saint Luke's Healthcare Utica NY
Finley Hospital Dubuque IA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Harbor Hospital Center Baltimore MD
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Indiana University Health Methodist Hospital Indianapolis IN
Inspira Medical Center Vineland Vineland NJ
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York NY
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Louisiana State University Health Science Center New Orleans LA
Loyola University Medical Center Maywood IL
Lutheran General Hospital Park Ridge IL
M D Anderson Cancer Center Houston TX
Maine Medical Center- Scarborough Campus Scarborough ME
Mainline Health CCOP Wynnewood PA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
McLaren Cancer Institute - Flint Flint MI
Mercy Hospital Pittsburgh PA
Methodist Medical Center of Illinois Peoria IL
Metro-Minnesota CCOP St. Louis Park MN
Miami Cancer Institute Miami FL
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor MI
Mills-Peninsula Medical Center San Mateo CA
Missouri Valley Cancer Consortium Omaha NE
Mobile Infirmary Medical Center Mobile AL
Moffitt Cancer Center Tampa FL
Montefiore Medical Center - Moses Campus Bronx NY
Mount Carmel Health Center West Columbus OH
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa OK
Nevada Cancer Research Foundation CCOP Las Vegas NV
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn NY
North Shore-LIJ Health System CCOP Manhasset NY
Northern Indiana Cancer Research Consortium South Bend IN
Northridge Hospital Medical Center Northridge CA
Northwestern University Chicago IL
Novant Health Forsyth Medical Center Winston Salem NC
Ohio State University Comprehensive Cancer Center Columbus OH
Peninsula Regional Medical Center Salisbury MD
Penn Radiaition Oncology, Pennsylvania Hospital Philadelphia PA
Penn State University and The Milton S. Hershey Medical Ctr Hershey PA
Pomona Valley Hospital Medical Center Pomona CA
Presbyterian Kaseman Hospital Albuquerque NM
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Alaska Medical Center Anchorage AK
Radiation Oncology Affiliates of Maryland Baltimore MD
Radiation Oncology Associates of Albuquerque Albuquerque NM
Radiological Associates of Sacramento Sacramento CA
Reading Hospital Reading PA
Regional Hospital of Scranton Scranton PA
Roswell Park Cancer Institute Buffalo NY
Saint Agnes Medical Center Fresno CA
Saint Joseph Mercy Hospital Ann Arbor MI
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Saint Luke's University Hospital-Bethlehem Campus Bethlehem PA
Saint Peter's University Hospital New Brunswick NJ
Saint Vincent Anderson Regional Hospital/Cancer Center Anderson IN
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Sinai Hospital of Baltimore Baltimore MD
Southeast Cancer Control Consortium CCOP Winston Salem NC
Sparrow Hospital Lansing MI
St Joseph's Hospital Medical Center Stockton CA
St. Francis Medical Center Trenton NJ
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Health Western Division Cancer Research Group Novato CA
The James Graham Brown Cancer Center at University of Louisville Louisville KY
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Tom Baker Cancer Centre Calgary, Alberta
Trinity Cancer Care Center Minot ND
UCLA Medical Center Los Angeles CA
UH Seidman Cancer Center at Salem Regional Medical Center Salem OH
University of California Davis Comprehensive Cancer Center Sacramento CA
University of California Irvine Medical Center Irvine CA
University of Cincinnati/Barrett Cancer Center Cincinnati OH
University of Colorado Hospital Aurora CO
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of Hawaii Cancer Center Honolulu HI
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami FL
University of Michigan Comprehensive Cancer Center Ann Arbor MI
University of Missouri - Ellis Fischel Columbia MO
University of New Mexico Cancer Center Albuquerque NM
University of New Mexico Cancer Center Albuquerque NM
University of Pennsylvania Medical Center Philadelphia PA
University of South Alabama Mobile AL
University of Texas Medical Branch Galveston TX
University of Utah Health Science Center Salt Lake City UT
University of Wisconsin Hospital and Clinics Madison WI
UPMC-Magee Womens Hospital Pittsburgh PA
UPMC-Presbyterian Hospital Pittsburgh PA
Upstate Carolina CCOP Spartanburg SC
Utah Valley Regional Medical Center Provo UT
Valley Medical Oncology Consultants Pleasanton CA
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
Washington Cancer Institute Washington DC
Wayne State University/Karmanos Cancer Institute Detroit MI
WellSpan Health-York Hospital York PA
West Allis Memorial Hospital West Allis WI
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wheaton Franciscan Cancer Care-All Saints Racine WI
Wheeling Hospital/Schiffler Cancer Center Wheeling WV
William Beaumont Hospital-Royal Oak Royal Oak MI
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 4/13/2011

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