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RTOG 9906 Protocol Information

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A Phase I/II Trial In Patients With Muscle-Invading Bladder Cancer of Transurethral Surgery Plus Taxol, Cisplatin and BID Irradiation Followed by Either Selective Bladder Preservation or Radical Cystectomy and Adjuvant Chemotherapy
Protocol Documents
Current Version Date: 4/30/2001
Principal Investigator: Donald S. Kaufman, M.D.
Primary Objective:

To evaluate the safety and tolerance of induction chemo-radiotherapy by Taxol, Cisplatin, and Irradiation (TCI). To be followed by radical cystectomy if the initial tumor response is incomplete or by consolidation TCI if the tumor has cleared. Four cycles of outpatient adjuvant gemcitabine-cisplatin chemotherapy is then given. A protocol completion rate of 90% is sought.

Patient Population:

Patients with muscle invading carcinoma of the bladder, all histologies. AJC Stages cT2-T4a, cNX or pN0, M0, no histologic evidence of tumor invasion into the stroma of the prostate, no tumor-related hydronephrosis; creatinine clearance >= 60ml/minute, platelets = 100,000, Zubrod status < 1, ANC > 1800, adequately functioning bladder, no prior chemotherapy or pelvic RT

 

APPENDIX VII

Target Accrual: 81
Current Accrual: 84
Status: Terminated
Date: 11/5/2013
Participating Sites:
21st Century Oncology Ft. Myers FL
Advocate Good Shepherd Hospital Barrington IL
Advocate Lutheran General Hospital Park Ridge IL
AnMed Health Cancer Center Anderson SC
Bay Area Tumor Institute Oakland CA
Bay Medical Center Panama City FL
Borgess Medical Center Kalamazoo MI
Bronson Methodist Hospital Kalamazoo MI
Cancer Treatment Center Wooster OH
Case Western Reserve University Cleveland OH
Cleveland Clinic Akron General Akron OH
Cleveland Clinic Foundation Cleveland OH
Columbia Saint Mary's Water Tower Medical Commons Milwaukee WI
Cottonwood Hospital Medical Center Murray UT
Cross Cancer Institute Edmonton, Alberta
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Dixie Medical Center Regional Cancer Center East St. George UT
Einstein Medical Center Philadelphia Philadelphia PA
Finley Hospital Dubuque IA
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Halifax Health Medical Center-Centers for Oncology Daytona Beach FL
Holy Cross Hospital Fort Lauderdale FL
Inspira Medical Center Vineland Vineland NJ
Intermountain Medical Center Murray UT
Jupiter Medical Center Jupiter FL
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
LDS Hospital Salt Lake City UT
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Logan Regional Hospital Logan UT
Mainline Health CCOP Wynnewood PA
Massachusetts General Hospital Cancer Center Boston MA
McGill University Department of Oncology Montreal
McKay-Dee Hospital Center Ogden UT
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood FL
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy San Juan Medical Center Carmichael CA
Methodist Hospital Philadelphia PA
Miami Cancer Institute Miami FL
Monmouth Medical Center Long Branch NJ
Mount Sinai Medical Center Miami Beach FL
Nevada Cancer Research Foundation CCOP Las Vegas NV
Northeast Radiation Oncology Center Dunmore PA
Northwest Community Clinical Oncology Program Tacoma WA
Northwest Community Hospital Arlington Heights IL
Providence Alaska Medical Center Anchorage AK
Radiation Oncology Associates of W. Alabama PC Tuscaloosa AL
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Rutherford Hospital Rutherfordton NC
Saint John Medical Center Tulsa OK
Saint Joseph Regional Medical Center-Mishawaka Mishawaka IN
Sandra L Maxwell Cancer Center Cedar City UT
Santa Rosa Memorial Hospital CCOP Santa Rosa CA
Southeast Cancer Control Consortium CCOP Winston Salem NC
Southwestern Vermont Medical Center Bennington VT
Spartanburg Medical Center Spartanburg SC
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Medical Center Sacramento Sacramento CA
The Research Institute of the McGill University Health Centr Montreal
Thomas Jefferson University Hospital Philadelphia PA
Trinity Cancer Care Center Minot ND
UNC Lineberger Comprehensive Cancer Center Chapel Hill NC
University of Alabama at Birmingham Cancer Center Birmingham AL
University of California Davis Comprehensive Cancer Center Sacramento CA
University of Florida Health Science Center - Gainesville Gainesville FL
University of Florida Health Science Center - Jacksonville Jacksonville FL
University of South Alabama Mobile AL
University of Vermont Medical Center Burlington VT
Upstate Carolina CCOP Spartanburg SC
Utah Cancer Specialists-Salt Lake City Salt Lake City UT
Utah Valley Regional Medical Center Provo UT
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virtua Memorial Mount Holly NJ
West Penn Hospital Pittsburgh PA
Western Oncology Research Consortium Portland OR
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Updated: 11/12/2013

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