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RTOG 9914 Protocol Information

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A Phase II Trial of Concomitant Boost Radiation and Concurrent Cisplatin for Advanced Head and Neck Carcinomas
Protocol Documents
Current Version Date: 8/25/2000
Principal Investigator: K. Kian Ang, M.D.
Primary Objective:
  • To determine the rate of local-regional recurrence at one year.
  • To determine the feasibility of treatment delivery, patient tolerance, acute and late toxicities.
  • To determine the overall survival, disease-free survival, and distant relapse rates of patients with relatively advanced HNSCC treated with this regimen.

 

Patient Population:
  • Histologic proof of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx
  • Stage III-IV disease (T3-4, N1-3, M0)
  • Zubrod status 0-1
  • AGC ≥2000, platelets ≥100,000, bilirubin 1.5, serum creatinine 1.5 mg %
  • SGOT or SGPT 2 x upper normal, creatinine clearance ≥50 ml/min.
  • No clinically significant heart disease
  • No prior radiation treatment to the head and neck or any prior chemotherapy
  • Patients with prior malignancy ≥3 years ago are eligible (simultaneous primaries are ineligible)
  • Signed study-specific consent form prior to study entry
Target Accrual: 56
Current Accrual: 84
Status: Terminated
Date: 6/30/2010
Participating Sites:
21st Century Oncology, Inc. Ft. Myers FL
Akron General Medical Center Akron OH
Alta Bates Hospital Comprehensive Cancer Center Berkeley CA
Baptist Cancer Institute Jacksonville FL
California Pacific Medical Center-Pacific Campus San Francisco CA
Cancer Care Center, Inc Salem OH
Cancer Treatment Center Wooster OH
Cape Cod Hospital Hyannis MA
Christiana Care Health System-Christiana Hospital Newark DE
Community Medical Center Toms River NJ
Community Memorial Hospital Menomonee Falls WI
CoxHealth South Hospital Springfield MO
Dayton CCOP Kettering OH
Delaware County Memorial Hospital Drexel Hill PA
Einstein Medical Center Philadelphia Philadelphia PA
Elliot Hospital Manchester NH
Enloe Medical Center Chico CA
Faxton-Saint Luke's Healthcare Utica NY
Finley Hospital Dubuque IA
Fox Chase Cancer Center Philadelphia PA
Froedtert and the Medical College of Wisconsin Milwaukee WI
Greenville Health System Cancer Institute-Eastside Greenville SC
Gulf Coast Cancer Treatment Center Panama City FL
Gundersen Lutheran Medical Center La Crosse WI
Halifax Hospital ROC Daytona Beach FL
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse NY
Hunter Holmes McGuire Veterans Administration Medical Center Richmond VA
Indiana University Health Ball Memorial Hospital, Inc. Muncie IN
Ingalls Memorial Hospital Harvey IL
Inspira Medical Center Vineland Vineland NJ
Julie and Ben Rogers Cancer Institute Beaumont TX
Kalamazoo CCOP-West Michigan Cancer Center Kalamazoo MI
Kansas City CCOP Prairie Village KS
Lehigh Valley Hospital-Cedar Crest Allentown PA
Liberty Hospital Liberty MO
Loma Linda University Medical Center Loma Linda CA
M D Anderson Cancer Center Houston TX
Marin General Hospital Greenbrae CA
Massachusetts General Hospital Boston MA
Mercy Catholic Medical Center - Fitzgerald Darby PA
Mercy General Radiation Oncology Center Sacramento CA
Mercy Hospital Pittsburgh PA
Mercy San Juan Medical Center Carmichael CA
Methodist Cancer Center Omaha NE
Mills-Peninsula Medical Center San Mateo CA
Moffitt Cancer Center Tampa FL
Monmouth Medical Center Long Branch NJ
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima WA
Northern Indiana Cancer Research Consortium South Bend IN
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield MO
ProHealth Oconomowoc Memorial Hospital Oconomowoc WI
ProHealth Waukesha Memorial Hospital Waukesha WI
Providence Alaska Medical Center Anchorage AK
Radiological Associates of Sacramento Sacramento CA
Regional Hospital of Scranton Scranton PA
Saint Agnes Medical Center Fresno CA
Saint Vincent Hospital Cancer Center Green Bay Green Bay WI
Scott and White Memorial Hospital Temple TX
State University of New York Downstate Medical Center Brooklyn NY
Summa Akron City Hospital/Cooper Cancer Center Akron OH
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn CA
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park CA
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville CA
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville CA
Sutter Health Western Division Cancer Research Group Novato CA
Sutter Medical Center Sacramento Sacramento CA
The James Graham Brown Cancer Center at University of Louisville Louisville KY
Trinity Cancer Care Center Minot ND
UCSF Medical Center-Mount Zion San Francisco CA
UF Cancer Center at Orlando Health Orlando FL
University of Alabama at Birmingham Cancer Center Birmingham AL
University of Missouri - Ellis Fischel Columbia MO
University of Pennsylvania Medical Center Philadelphia PA
University of Pennsylvania/Abramson Cancer Center Philadelphia PA
Upstate Carolina CCOP Spartanburg SC
Virginia Commonwealth University/Massey Cancer Center Richmond VA
Virginia Mason CCOP Seattle WA
Virginia Mason Medical Center Seattle WA
Virtua Memorial Mount Holly NJ
Wake Forest University Health Sciences Winston-Salem NC
West Florida Cancer Institute Pensacola FL
West Penn Hospital Pittsburgh PA
Wyoming Valley Health Care System - Hospital Wilkes-Barre PA
Zablocki VA Medical Center-Wood Milwaukee WI
Updated: 4/13/2011

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