Frequently Asked Questions

All studies listed on the RTOG Foundation Studies webpage are actively accruing RTOG Foundation studies.

The RTOG Foundation had its origins in 1997 when the RTOG Fund under the auspicious of the American College of Radiology, the grant holder for the Radiation Therapy Oncology Group (RTOG), was created for the purpose of receiving and allocating corporate and private donations to allow the Group to sustain and expand important activities critical to its research mission. In August 2013, the RTOG Foundation incorporated as a nonprofit foundation in the Commonwealth of Pennsylvania and in July 2014, RTOG Foundation, Inc., received its 501(c)3 nonprofit status from the Internal Revenue Service

The RTOG Foundation continues the NCI-funded research of the Radiation Therapy Oncology Group through its membership in NRG Oncology. In addition it has developed a portfolio of industry-funded research partnerships that seek to further our understanding of effective therapies to improve the survival and quality of life of patients with cancer.

RTOG Foundation has maintained its relationships with the core members from the legacy Radiation Therapy Oncology Group and is able to access new members through its membership in NRG Oncology. Today, RTOG is a dynamic multidisciplinary research group with vigorous participation by physicians and other investigators at many of NCI’s designated cancer centers, major community centers, and many of the major academic and regional centers of Canada. RTOG also has a strong international presence with access to sites on four continents. This participation includes leadership from medical oncologists, surgical oncologists, pathologists, and laboratory scientists, as well radiation oncologists.

Access is granted per study to participating sites (those who have an executed Master Service Purchased Agreement and Study-Specific Statement of Work) or sites interested in participating with an executed Confidentiality and Non-Disclosure Agreement on file. If you are interested in learning more about a specific trial, please send an email to and include the name of the trial in your email.

The RTOG Foundation Manual of Operations provides general information about participation in RTOG Foundation studies. Study-specific manuals explain the oversight, reporting and monitoring/auditing requirements for each trial. The study-specific manuals are available to the staff at sites participating in that trial.

RTOG Foundation trials are conducted outside of the NRG Oncology NCI portfolio and infrastructure. For example, regulatory collection occurs at RTOG Headquarters and not through the CTSU.

At the present time, RTOG Foundation studies are not membership based. There are no minimum accrual requirements. Data submission quality and timeliness is monitored and sites are regularly audited.

Cases enrolled to RTOG Foundation trials may count towards NRG membership requirements as posted on the NRG website at

Yes, when a trial is open to sites in Canada, the RTOG Foundation will apply for the CTA with Health Canada for trials involving drugs.

Participate in RTOG Research

To participate as an RTOG study investigator, your organization must be part of the RTOG Foundation network. Patients who wish to participate in a study must be under the care of an RTOG participating investigator. For additional information, email or call 1-215-574-3173.

See our clinical trials